5-Bromo-2-Chlorobenzoic Acid

Product Name:5-Bromo-2-Chlorobenzoic Acid
CAS NO:21739-92-4
Molecular Formula:C7H4BrClO2
Formula Weight:235.46
Usage:Dapagliflozin Intermediates

Model:CAS NO:21739-92-4

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Product Description

5-Bromo-2-Chlorobenzoic Acid

CAS NO:21739-92-4

Usage:Dapagliflozin Intermediates

Chemical Name	5-Bromo-2-chlorobenzoic Acid
Synonyms	2-Chloro-5-bromobenzoic acid
CAS Number	21739-92-4
Molecular Formula	C₇H₄BrClO₂
Appearance	White to Off-White Solid
Melting Point	>155°C (dec.)
Molecular Weight	235.46
Storage	-20°C Freezer
Solubility	DMSO (Slightly), Methanol (Slightly)
Category	Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications	5-Bromo-2-chlorobenzoic acid is used as a starting material in the synthesis of Dapagliflozin (D185370), a selective sodium-glucose cotransporter-2 inhibitor that reduces renal glucose reabsorption and is used to treat patients with type 2 diabetes.

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Skin corrosion/irritation (Category 2), H315
Serious eye damage/eye irritation (Category 2), H319
Specific target organ toxicity, single exposure; Respiratory tract irritation (Category 3), H335
2.2. GHSLabelelements,includingprecautionarystatements:
Signal word Warning
Hazard statement(s).
H315 Causes skin irritation

H319 Causes serious eye irritation

H335. May cause respiratory irritation

Precautionary statement(s).
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 If on skin: Wash with soap and water.
P304+P340+P312 If inhaled: Remove victim to fresh air and keep at rest in a position comfortable for breath-
ing. Call a POISON CENTER or doctor/physician if you feel unwell.
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P332+P313 If skin irritation occurs: Get medical advice/attention.

P337+P313 If eye irritation persists: get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

P403+P233 Store in a well ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an approved waste disposal plant.

Handling and storage
Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electro-
static charge. For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent
leakage.
Specific end use(s): Laboratory chemicals, for scientific research and development only.

Application Dapagliflozin intermediate

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