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How much do you know about minocycline hydrochloride?
2022-08-06
Minocycline hydrochloride is commonly used as its hydrochloride, which is yellow crystalline powder, odorless, bitter in taste, and can cause deterioration when exposed to light. Soluble in water, slightly soluble in ethanol, easily soluble in alkali metal hydroxide or carbonate solution.
Minocycline hydrochloride is a broad-spectrum antibiotic and is effective against tetracycline-sensitive or resistant Staphylococcus aureus; against Staphylococcus aureus, Actinomyces asterixis, Streptococcus pneumoniae and bacteria-like microorganisms, Neisseria gonorrhoeae The effect is slightly stronger than other tetracyclines, and the antibacterial strength against Escherichia coli, Proteus, Salmonella, Shigella, Klebsiella, and Pseudomonas is similar to that of tetracyclines. Its hydrochloride is commonly used, which is yellow crystalline powder, odorless, bitter in taste, and can cause deterioration when exposed to light. Soluble in water, slightly soluble in ethanol, easily soluble in alkali metal hydroxide or carbonate solution.
It is a high-efficiency, fast-acting, long-acting new semi-synthetic tetracycline preparation, the antibacterial effect is the strongest in this genus, and the antibacterial spectrum is similar to that of doxycycline. The effect is 2-4 times stronger than that of tetracycline, and also better than doxycycline, metacycline, and oxytetracycline. Can overcome tetracycline-resistant Staphylococcus aureus, Streptococcus, Escherichia coli, Staphylococcus aureus is not easy to produce resistance to this product. Oral absorption is rapid, and it is not affected by food, and it is widely distributed. t1/2=12.6h. For urinary tract, gastrointestinal tract, gynecology, skin, bone marrow, eye, ear, nose, throat infection and male gonorrhea. This product can still be used for adjuvant treatment of amebiasis.
Dosage of Minocycline Hydrochloride:
oral. Pediatric dose: over 8 years old first dose: 4mg/kg later: 2-4mg/2-4mg/(kg. times) Adult dose: first time: 0.2g, later 0.1g/time, once/12h Gonorrhea: 300mg, once Clothes.
1. Calcium, aluminum and other metal ions can affect the absorption of this product and should be avoided.
2. The adverse reactions are similar to those of tetracycline.
3. Children can have yellow teeth, and babies can cause bulging of the front chimney.
4. It should be used with caution in patients with liver and renal insufficiency.
5. Disabled for children under 8 years old, pregnant women and drivers.
6. It can cause vestibular dysfunction (dizziness, ataxia), but it can be recovered after stopping the drug.
Minocycline hydrochloride is a broad-spectrum antibiotic and is effective against tetracycline-sensitive or resistant Staphylococcus aureus; against Staphylococcus aureus, Actinomyces asterixis, Streptococcus pneumoniae and bacteria-like microorganisms, Neisseria gonorrhoeae The effect is slightly stronger than other tetracyclines, and the antibacterial strength against Escherichia coli, Proteus, Salmonella, Shigella, Klebsiella, and Pseudomonas is similar to that of tetracyclines. Its hydrochloride is commonly used, which is yellow crystalline powder, odorless, bitter in taste, and can cause deterioration when exposed to light. Soluble in water, slightly soluble in ethanol, easily soluble in alkali metal hydroxide or carbonate solution.
It is a high-efficiency, fast-acting, long-acting new semi-synthetic tetracycline preparation, the antibacterial effect is the strongest in this genus, and the antibacterial spectrum is similar to that of doxycycline. The effect is 2-4 times stronger than that of tetracycline, and also better than doxycycline, metacycline, and oxytetracycline. Can overcome tetracycline-resistant Staphylococcus aureus, Streptococcus, Escherichia coli, Staphylococcus aureus is not easy to produce resistance to this product. Oral absorption is rapid, and it is not affected by food, and it is widely distributed. t1/2=12.6h. For urinary tract, gastrointestinal tract, gynecology, skin, bone marrow, eye, ear, nose, throat infection and male gonorrhea. This product can still be used for adjuvant treatment of amebiasis.
Dosage of Minocycline Hydrochloride:
oral. Pediatric dose: over 8 years old first dose: 4mg/kg later: 2-4mg/2-4mg/(kg. times) Adult dose: first time: 0.2g, later 0.1g/time, once/12h Gonorrhea: 300mg, once Clothes.
1. Calcium, aluminum and other metal ions can affect the absorption of this product and should be avoided.
2. The adverse reactions are similar to those of tetracycline.
3. Children can have yellow teeth, and babies can cause bulging of the front chimney.
4. It should be used with caution in patients with liver and renal insufficiency.
5. Disabled for children under 8 years old, pregnant women and drivers.
6. It can cause vestibular dysfunction (dizziness, ataxia), but it can be recovered after stopping the drug.
